The Effect of Magnesium Intake on Stroke Incidence

The effect of magnesium on stroke has been consistently discussed less, and the results of previous studies have been contradictory. We reviewed the latest literature and quantified robust evidence of the association between magnesium intake and stroke risk.

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Magnesium in Stroke Treatment

Magnesium is involved in multiple physiological processes that may be relevant to cerebral ischaemia, including antagonism of glutamate release, NMDA receptor blockade, calcium channel antagonism, and maintenance of cerebral blood flow. Systemically administered magnesium at doses that double physiological serum concentration significantly reduces infarct volume in animal models of stroke, with a window of up to six hours after onset and favourable dose-response characteristics when compared with previously tested neuroprotective agents. Small clinical trials have reported benefit, but results are not statistically significant in systematic review. A large ongoing trial (IMAGES) will report in 2003–4 and further trials are planned.

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Magnesium-Rich Foods May Lower Stroke Risk

People who eat more foods rich in the mineral magnesium appear to reduce their odds of having a stroke, a new study shows.

The link between magnesium in the diet and stroke risk was strongest for ischemic stroke, which is when a clot blocks a blood vessel in the brain.

Researchers found that the risk for ischemic stroke, the most common type of stroke in older people, was reduced by 9% for each additional 100 milligrams of magnesium a person consumed each day.

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Serum and Dietary Magnesium and Risk of Ischemic Stroke

The authors sought to examine the relation between serum or dietary magnesium and the incidence of ischemic stroke among blacks and whites. Between 1987 and 1989, 14,221 men and women aged 45–64 years took part in the first examination of the Atherosclerosis Risk in Communities Study cohort. The incidence of stroke was ascertained from hospital records. Higher serum magnesium levels were associated with lower prevalence of hypertension and diabetes mellitus at baseline. During the 15-year follow-up, 577 ischemic strokes occurred. Serum magnesium was inversely associated with ischemic stroke incidence. The age-, sex-, and race-adjusted rate ratios of ischemic stroke for those with serum magnesium levels of :::1.5, 1.6, 1.7, and 2:1.8 mEq/L were 1.0, 0.78 (95% confidence interval (CI): 0.62, 0.96), 0.70 (95% CI: 0.56, 0.88), and 0.75 (95% CI: 0.59, 0.95) (Ptrend 0.005). After adjustment for hypertension and diabetes, the rate ratios were attenuated to nonsignficant levels. Dietary magnesium intake was marginally inversely associated with the incidence of ischemic stroke (Ptrend 0.09). Low serum magnesium levels could be associated with increased risk of ischemic stroke, in part, via effects on hypertension and diabetes.

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Strokes are the #4 cause of death and the
#1 cause of disability in the United States

Today you may be happy, enjoying life, feeling good and having a great day. But, imagine tomorrow waking up and not be able to swallow or talk. No warning. You cannot ask for help. You cannot tell anyone that something is wrong. Your cries for help will not be heard. No one can hear you. You may even have medical personnel around you who do nothing or who actually incorrectly diagnose you and make you worse. You cannot tell them what is wrong. Precious time starts slipping by.

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